KA-LOK NG 吳家樂
Professor, 教授
姓名:吳家樂 (Ka-Lok Ng)
地址: 台灣 41354 台中市 霧峰區 柳豐路500號
500. Lioufeng road, Wufeng, Taichung, Taiwan 41354
連絡電話/E-mail/(04)23323456 ext. 1856,ppiddi@gmail.com, klng@asia.edu.tw
Personal Data
Phone/E-mail (O) 886-423323456x1856, (F) 886-4-23321019, E-mail: ppiddi@gmail.com
Address Asia University, 500 Lioufeng road, Wufeng Shiang, Taichung, Taiwan 41354
Experience
Education 1990, Ph.D in Physics, Vanderbilt University, USA, GPA 2.88/3.00.
1983, Honours Diploma in Physics, Hong Kong Baptist College, GPA 3.57/4.
Work Experience
08/2017-present, Distinguish Professor, Department of Bioinformatics and Medical Engineering, Asia University, Taiwan.
08/2003-07/2017, Associate Professor, Department of Bioinformatics, Asia University, Taiwan.
02/2000-07/2003, Assistant Professor, Department of Information Management, Ling Tung University, Taiwan
07/1998-01/2000, IT Engineer, National Health Research Institute
11/1995-06/1998, Supercomputer IT Engineer, Silicon Graphics Inc. Taiwan
12/1992-10/1995, Postdoc. Fellow, Institute of Physics, Academia Sinica
12/1991-11/1992, Postdoc. Fellow, Physics dept., National Taiwan University
12/1990-11/1991, Postdoc. Fellow, Physics dept., National Tsing Hua Univ.
Visiting Scholar 07/2001 - 08/2001 Institute of Physics, Academia Sinica, Taiwan
07/2002 - 09/2002 Institute of Physics, Academia Sinica, Taiwan
07/2003 - 09/2003 Institute of Physics, Academia Sinica, Taiwan
07/2004 - 09/2004 Institute of Physics, Academia Sinica, Taiwan
Research Interests
Network biology or so-called systems biology
Cancer disease protein study
Next-generation sequence data analysis
The role of epigenetics in cancer biology
Applications of Quantum Machine Learning
Achievement
Editor-in-Chief, WSEAS Transactions on Biology and Biomedicine 2010/09 -2014/2
Editorial Board, IST Transactions of Biomedical Sciences and Engineering 2009/12 - present
Review Editor, Frontiers in Genomic Assay Technology, 2011/10 - present
Editorial Board, EAI Endorsed Transactions on Bioengineering and Bioinformatics, 2020/4-present
Editorial Board, Journal of Bioinformatics, 2013/08 - present
Editorial Board, Austin Journal of Computational Biology and Bioinformatics, 2014/07 - present
Invited speaker, Jung Kyoon Choi, and I am organizing a session for the 79th Annual Meeting of the Japanese Cancer Association (JCA) that will be held in Kyoto between September 26 (Thu) and September 28 (Sat) in 2019. I was wondering if you would be able to speak in "Cancer research using artificial intelligence" session.
Invited speaker, IMECS2018, 2018/3/15, Hong Kong. DISSECTING THE COMPLEX NATURE OF THE BIOLOGICAL NETWORKS
Invited speaker, IMECS2017, 2017/3/17, Hong Kong. In silico Study of Epigenetic Regulation in Cancer Formation
Invited speaker, IMECS2016, 2016/3/17, Hong Kong. Computational Approach for Drug Repositioning in Cancer Therapy and Vascular Smooth Muscle Cell Diseases
Invited speaker, International Conference on Big Data and Biomedical Informatics (BDBI-2015), 2015/12/9-10, Asia University, Taiwan
Invited speaker, IMECS2015, 2015/3/18, Hong Kong. Graph Theory - a Tool for Studying Biological Regulatory Networks
Invited speaker, ICBB‘12, 2012/12/29-31, Montreux, Switzerland
Program committee, InCoB’2018, 2018/06/01 – 2018/09/28, India
Conference PC member, InCoB’2017, 2017/07/01- 2017/09/22, China
Conference area chair (Taiwan), BIBE’2017, 2017/07/01- 2017/10/26, Washington DC, USA
Program co-chair, BIBE2018, 2018/10/29-31, Taiwan
Conference co-chair, ICB’2019, Hong Kong
Conference co-chair, ICB’2018, Hong Kong
Conference co-chair, ICB’2017, Hong Kong
Conference co-chair, ICB’2016, Hong Kong
Program co-chair, BIBE 2016, 2016/10/31-11/2, Taiwan
Conference co-chair, ICB’2015, Hong Kong
Conference co-chair, BIBE 2011, 2011/10/24-25, Taiwan
Program committee, Genome Informatics, 2016/10/31-11/25, Shanghai, China
Program committee, APBC 2015, 2015/1/21-23, Taiwan
Session Chair, International Conference on Bioinformatics, ICB2018, 2018/3/14-16, 18, Hong Kong
Session Chair, IMECS2019, 2019/3/14, ICDMA Invited Speech & ICDMA I,Hong Kong
Session Chair, IMECS 2018, 2018/3/15, Hong Kong
Session Chair, IMECS 2015, 2015/3/16 & 18, Hong Kong
Session Chair, IMECS 2014, 2014/3/13, Hong Kong
Session Chair, iCBBE 2012, Oral_1: Gene, DNA and RNA, 2012/05/17-20
Session Chair, BIOCOMP 2013, Topics in computational biology & bioinformatics, 2013/7/25 European Society for Applied Sciences and Development
Conference Proceedings Editor, five volumes, from 2011 to 2012
International Liaision, BIO2013, 2013/07/16-19
International Liaision, BIOMED2013, 2013/09/28-30
Reviewer, Behavioural Brain Research, 2019/10/06
Reviewer, Recent Patents on Computer Science, 2019/04/15
Reviewer, OncoTargets and Therapy,2019/02/16
Reviewer, IET Systems Biology, 2019/02/13-2019/05/03
Reviewer, Nature Scientific Reports, 2016/12/30
Reviewer, Genome Informatics, 2016/10/31-11/25, Shanghia, China
Reviewer, BIBE 2016, 2016/10/31-11/2, Taiwan
Reviewer, Bioinformatics and Biology Insights, 2016/01/14
Reviewer, Biomedical Engineering, 2016/09/16
Reviewer, Bioinformatics 2018/5/14, 2010/05, 2015/1/23, 2015/8/10
Reviewer, International Journal of Bioinformatics Research and Applications (IJBRA),2010/05
Reviewer, Advances and Applications in Bioinformatics and Chemistry, 2011/05
Reviewer, Open Access Bioinformatics, 2011/05, 2013/07
Reviewer, Bioinformatics and Biology Insights, 2011/09/29
Reviewer, Biomedical Engineering and Computational Biology, 2011/09/29
Reviewer, Biomedical Informatics Insights, 2011/09/29, 2013/09/29
Reviewer, Gene Regulation and Systems Biology, 2011/09/29
Reviewer, Plant Omics Journal, 2013/07
Reviewer, BMC Research Notes, 2013/08/24, 2014/01/04
Reviewer, Journal of Bioinformatics, 2013/12/22
Publications
SCI = Science Citation Index
EI = Engineering Index
EIc = Engineering Index Conference
PIJ = Peer-review International Journal
[SCI] Eskezeia Y Dessie, Jeffrey J.P. Tsai, Jan-Gowth Chang*, Ka-Lok Ng* (2021). A novel miRNA-based classification model of risks and stages for clear cell renal cell carcinoma patients. BMC Bioinformatics, 22, 270 (2021).
[SCI] Eskezeia Yihunie Dessie, Siang-Jyun Tu, Hui-Shan Chiang, Jeffrey J.P. Tsai, Ya-Sian Chang *, Jan-Gowth Chang *, Ka-Lok Ng * (2021). Construction and Validation of a Prognostic Gene-Based Model for Overall Survival Prediction in Hepatocellular Carcinoma Using an Integrated Statistical and Bioinformatic Approach. International Journal of Molecular Sciences, 22, 1632. Feb. 2021
[SCI] Ka-Lok Ng and Y-h Taguchi (2020), Identification of miRNA signatures for kidney renal clear cell carcinoma using the tensor-decomposition method, Scientific Reports 10, article number 15149. Sep. 16, 2020
[SCI] Nilubon Kurubanjerdjit & Ka-Lok Ng (2020). A database of integrated molecular and phytochemical interactions of the foxm1 pathway for lung cancer, Journal of Biomolecular Structure & Dynamics, https://www.tandfonline.com/doi/abs/10.1080/07391102.2020.1810777?journalCode=tbsd20
[SCI] C-H Huang, E Zaenudin, JJP Tsai, N Kurubanjerdjit, EY Dessie, K-L Ng. (2020). Dissecting Molecular Network Structures using a Network Subgraph Approach, PeerJ 8:e9556 DOI 10.7717/peerj.9556.
[SCI] Yu-Hsien Lin, Ya-Hsin Hsiao, Ka-Lok Ng, Yueh-Hsiung Kuo, Yun-Ping Lim, Wen-Tsong Hsieh (2020). Physalin A attenuates inflammation through down-regulating c-Jun NH2 kinase phosphorylation/Activator Protein 1 activation and up-regulating the antioxidant activity. Toxicology and Applied Pharmacology, 2020 Jul 4;402:115115. Sep. 2020
[SCI] Shun-Tsung Chen, Chien-Hung Huang, Victor C. Kok, Jin-Shuei Ciou, Jeffrey J. P. Tsai, Nilubon Kurubanjerdjit, Chi-Ying F Huang, and Ka-Lok Ng* (2017). Drug repurposing and therapeutic anti-microRNA predictions in oxidized low-density lipoprotein-induced the proliferation of vascular smooth muscle cell-associated diseases, Journal of Bioinformatics and Computational Biology, 15[1], 1650043-1
[SCI] David Agustriawan, Chien-Hung Huang, Jim Jinn-Chyuan Sheu, Shan-Chih Lee, Jeffrey JP Tsai, Nilubon Kurubanjerdjit, Ka-Lok Ng* (2016). DNA Methylation-regulated microRNA Pathways in Ovarian Serous Cystadenocarcinoma: a Meta-analysis, Computational Biology and Chemistry, 65, 154-164,
[SCI] Chien-Hung Huang, Jin-Shuei Ciou, Shun-Tsung Chen, Victor C. Kok, Yi Chung, Jeffrey J. P. Tsai, Nilubon Kurubanjerdjit, Chi-Ying F. Huang, Ka-Lok Ng* (2016) Identify Potential Drugs for Cardiovascular Diseases Caused by Stress-induced Genes in Vascular Smooth Muscle Cells, PeerJ, 4:e2478; Sep 2016
[SCI] Chien-Hung Huang, Peter Mu-Hsin Chang, Chia-Wei Hsu, Chi-Ying Huang, Ka-Lok Ng* (2016) Drug Repositioning for Non-Small Cell Lung Cancer by Using Machine Learning Algorithms and Topological Graph Theory, BMC Bioinformatics 17[1]:13-26
[SCI] Praveen Kumar Korla, Jack Cheng, Chien-Hung Huang, Jeffrey J. P. Tsai, Yu-Hsuan Liu, Nilubon Kurubanjerdjit, Wen-Tsong Hsieh, Huey-Yi Chen, Ka-Lok Ng* (2015), FARE-CAFE: A Database of Functional and Regulatory Elements of Cancer-Associated Fusion Events, Database- The Journal of Biological Databases and Curation 2015; doi: 10.1093/database/bav086 (ISSN 0000-0000), 9/2015
[SCI] Chien-Hung Huang, Teng-Hung Chen, Ka-Lok Ng* (2015) Graph Theory and Stability Analysis of Protein Complex Interaction Networks, IET Systems Biology, 1-12 , Apr. 2016
[SCI] Chien-Hung Huang, Husi-Shun Peng and Ka-Lok Ng* (2015), Prediction of Cancer Proteins by Integrating Protein Interaction, Domain Frequency and Domain Interaction Data Using Machine Learning Algorithms, BioMed Research International, Volume 2015, Article ID 312047, Mar. 2015.
[SCI] Wen-Tsong Hsieh, Ke-Rung Tzeng, Jin-Shuei Ciou, Jeffrey J. P. Tsai, Nilubon Kurubanjerdjit, Chien-Hung Huang, Ka-Lok Ng* (2015). Transcription factor and microRNA-regulated network motifs for cancer and signal transduction networks, BMC Systems Biology, 9, (Suppl. 1):S5. 1/2015, Jan 2015
[SCI] Chien-Hung Huang, Peter Mu-Hsin Chang, Yong-Jie Lin, Cheng-Hsu Wang, Chi-Ying F Huang, Ka-Lok Ng* (2014). Drug Repositioning Discovery for Early and Late Stage Non-Small Cell Lung Cancer, BioMed Research International (Journal of Biomedicine and Biotechnology), Vol. 2014, Article ID 193817, 1-13
[EI] Nilubon Kurubanjerdjit, Jin-Shuei Ciou, Ke-Rung Tzeng, Ching-Yi Chen, Jeffrey J.P Tsai, Chien-Hung Huang, Ka-Lok Ng* (2014). The Role of A. thaliana MicroRNA-Regulated Protein-Protein Interaction Networks in Plant-Pathogen Interaction Study IAENG International Journal of Computer Science, 41[1], 141-147 May 2014
[EI] Chien-Hung Huang, Wen-Wei Zhuang, Ka-Lok Ng* (2014), An Integrated Web Platform on Disease-Associated Proteins, Journal of Chemical and Pharmaceutical Research, 6[1], 359-367.
[EI] Chien-Hung Huang, Li-Chi Chen, Chia-Tung Lee, Ka-Lok Ng* (2014). Finding all approximate palindromes of the string, WIT Transactions on Information and Communication Technologies, vol. 49[1], 553-559
[SCI] Charles CN Wang, Pei-Chun Chang, Ka-Lok Ng, Chun-Ming Chang, Phillip CY Sheu, Jeffrey JP Tsai (2014), A model comparison study of the flowering time regulatory network in Arabidopsis, BMC Systems Biology, 8,15, pp. 1-12 IF = 2.982,
[SCI] Chien-Hung Huang, Min-You Wu, Peter Mu-Hsin Chang, Chi-Ying Huang, Ka-Lok Ng* (2014), In silico Identification of Potential Targets and Drugs for Non-small Cell Lung Cancer, IET Systems Biology 8[1], 56-66, IF = 1.535
[SCI] Nilubon Kurubanjerdjit, Jeffrey J.P Tsai, Chien-Hung Huang, Ka-Lok Ng* (2014). Disturbance of A. thaliana microRNA-regulated pathways by Xcc bacterial effector proteins, Amino Acids 46(4), pp. 953-96, IF = 3.914
[SCI] Nilubon Kurubanjerdjit, Chien-Hung Huang, Yuliang Lee, Jeffrey J.P Tsai, Ka-Lok Ng* (2013) Prediction of microRNA-regulated protein interaction pathway in Arabidopsis using machine learning algorithms, Computers in Biology and Medicine, 43(11), 1645-1652, IF = 1.162, 39/86 = 45.3%, biology
[SCI] Chia-Wei Weng, Shan-Chin Lee, Yu-Liang Lee, Ka-Lok Ng* (2013). Analysis of the NCI-60 dataset for cancer-related microRNA and mRNA using expression profiles. Computational Biology and Chemistry, 44, 15-21. IF = 1.793
[SCI] Nilubon Kurubanjerdjit, Jeffrey J.P Tsai, Chen-Yu Sheu, Ka-Lok Ng* (2013). The prediction of protein-protein interaction of A. thaliana and X. campestris pv. campestris based on protein domain and interolog approaches, Plant OMICS, 6(6), 388-398. IF = 0.347
[SCI] Chien-Hung Huang, Szu-Yu Chou, Ka-Lok Ng* (2013). Improving protein complex classification accuracy using amino acid composition profile. Computers in Biology and Medicine, 43[1], 1196-1204. IF = 1.162
[SCI] Yng-Tay Chen †, Chang-Ching Wei †, Ka-Lok Ng † (first author, equal contribution) et al., (2013) Toll-like receptor 9 SNPs are susceptible to the development and progression of membranous glomerulonephritis: 27 years follow up in Taiwan." Renal Failure. 2013/08, DOI: 10.3109/0886022X.2013.828264
[EIc] Shun-Tsung Chen, Hsing-Fang Wu, Ka-Lok Ng* (2012) A platform for querying breast and prostate cancer-related microNA genes. International Conference on Bioinformatics and Biomedical Engineering (ICBBE 2012), 1[1], 271-274, Shanghai, May 17-20, 2012.
[PIJ] Ka-Lok Ng, C.H. Huang, M.C. Tsai (2010). Vertebrate microRNA genes and CpG-islands. WSEAS Transactions on Biology and BioMedicine 3[1], 73-81
[SCI] Ka-Lok Ng, Hsueh-Chuan Liu, and Shan-Chih Lee (2009). ncRNAppi – A tool for identifying disease-related miRNA and siRNA targeting pathways. Bioinformatics 25[1], 3199-3201, IF = 4.926
[EIc] Chia-Wei Weng, Chang-Chih Chiang, Ka-Lok Ng*, Chien-Hung Huang (2009). A platform for identifying microRNA targeting genes. Proceedings of the 2009 9th IEEE International Conference on Bioinformatics and BioEngineering, BIBE 2009, 1: 386-387
[EIc] Yu-Liang Lee, Jie-Wei Weng, Wen-Chin Chiang, Yi-Wen Lin, Ka-Lok Ng*, Jeffrey Jing-Pha Tsai, Chi-Ying Huang (2011) Investigating Cancer-related Proteins Specific Domain Interactions and Differential Protein Interactions caused by Alternative Splicing, IEEE International Conference on Bioinformatics and Bioengineering BIBE 2011, 1[1], 33-38
[EIc] Chien-Hung Huang, K-.T Chao and Ka-Lok Ng* (2011). Physiochemcial Features Study of Protein Complexes. IEEE International Conference on Computer Science and Information Technology. (IEEE ICCSIT 2011), vol. 3, pp. 525-528, Chengdu, China, Jun. 10-12, 2011
[EIc] Chien-Hung Huang, K-.T Chao and Ka-Lok Ng* (2011). Protein Complexes Subunits Interaction Topology and Sequence Identity. IEEE International Conference on Computer Research and development (IEEE ICCRD 2011), vol. 1, pp. 229-232 Shanghai, China, March 11-13, 2011
[SCI] Ka-Lok Ng, Jin-Shuei Ciou, Chien-Hung Huang (2010). Prediction of Protein Functions based on Function-function Correlation Relations. Computers in Biology and Medicine, 40, 300-305
[SCI] H.J. Shiu; K.L. Ng; J.F. Fang; R. C.T. Lee; C.H. Huang (2010). Data Hiding Methods Based upon DNA Sequences. Information Sciences, 180(11), 2196-2208
[EIc] Charles C.N. Wang, Ka-Lok Ng, Yu-Ching Chen, Phillip C.Y. Sheu and Jeffrey J.P. Tsai (2011) Simulation of Bacterial Chemotaxis by the Random Run and Tumble Model , IEEE International Conference on Bioinformatics and Bioengineering BIBE 2011 1[1] 228-233
[EIc] David Hecht et al., (2008). Biosemantic system: applications of structured natural language to biological and biochemical research. IEEE International Conference on Sensor Networks, Ubiquitous, and Trustworthy Computing. Taichung, Taiwan.
[SCI] Ka-Lok Ng and K.W. Ng (1996). “Large-angle polarization of the cosmic microwave background radiation and reionization” The Astrophysical Journal, 456, 413-421.
[SCI] Ka-Lok Ng and K.W. Ng (1995). “Gravity wave-induced polarization of the cosmic microwave background radiation.” The Astrophysical Journal, 445, 521-525.
[SCI] Ka-Lok Ng and K.W. Ng (1995). “Large-scale polarization of the cosmic microwave background radiation”, Phys. Rev. D51, 364-368.
[SCI] Ka-Lok Ng,H.Pois and T.C.Yuan (1989). “Higgs-boson decay into two gluinos”, Phys. Rev. D, 40, 1689-1692.
[SCI] Ka-Lok Ng (1990). “Neutrino magnet moment in N=1 minimal supergravity”, Z. Phys. C 48, 289-293.
[SCI] Ka-Lok Ng (1992). “Neutrino charge radius in the minimal supersymmetric standard model:, Z. Phys. C 55, 145-152.
[SCI] H.T.Cho and Ka-Lok.Ng (1993). “Spinor technique in graviton scattering processes”, Phys. Rev. D, 47, 1692-1698.
[SCI] Ka-Lok Ng (1993). “Gravitational form factors of the neutrino”, Phys. Rev. D, 47, 5187-5190.
[SCI] Ka-Lok Ng (1993). “Electromagnetic properties of the neutrino”, Chin. J. Phys. 31, 157-166.
[SCI] Ka-Lok Ng (1994)
“Radiative correction of the neutrino charge radius”, IL Nuovo Cimento 107A, 431-438.
[SCI] Ka-Lok Ng (1994). “Equivalence principle and discrete symmetries of Dirac and Majorana Fermions in gravitational field”, IL Nuovo Cimento 107B, 1143-1146.
Monograph
J.J.P.Tsai & Ka-Lok Ng (2017). Advanced Series in Electrical and Computer Engineering, Vol. 20, Computational methods with applications in bioinformatics analysis. World Scientific Publisher. 220pp, June 2017, ISBN: 978-981-3207-99-8. https://www.worldscientific.com/worldscibooks/10.1142/10393
J.J.P. Tsai & Ka-Lok Ng (2019). Advanced Series in Electrical and Computer Engineering , Vol. 21, Application of Omics, AI and Blockchain in Bioinformatics Research. World Scientific Publisher. 208pp, ISBN: 978-981-120-358-9, Nov., 2019, ISBN: 978-981-120-359-6.
https://www.worldscientific.com/worldscibooks/10.1142/11364
Proceedings Editor 國際研討會論文集編輯五集
Recent Researches in Chemistry, Biology, Environment and Culture, Editors: Vincenzo Niola, Ka-Lok Ng. Montreux, Switzerland. December 29-31, 2011, ISBN: 978-1-61804-060-2
MATHEMATICAL MODELS and METHODS in APPLIED SCIENCES, Editors: Razvan Raducanu, Nikos Mastorakis, Reinhard Neck, Vincenzo Niola, Ka-Lok Ng, G. Enescu University, Iasi, Romania, June 13-15, 2012, WSEAS Press, ISBN: 978-1-61804-098-5
Latest Advances in Acoustics and Music, Editors: Razvan Raducanu, Nikos Mastorakis, Reinhard Neck, Vincenzo Niola, Ka-Lok Ng, G. Enescu University, Iasi, Romania, June 13-15, 2012, WSEAS Press, ISBN: 978-1-61804-096-1
Latest Advances in Biology, Environment and Ecology, Editors: Razvan Raducanu, Nikos Mastorakis, Reinhard Neck, Vincenzo Niola, Ka-Lok Ng, G. Enescu University, Iasi, Romania, June 13-15, 2012, WSEAS Press, ISBN: 978-1-61804-097-8
Latest Advances in Information Science, Circuits and Systems Editors: Razvan Raducanu, Nikos Mastorakis, Reinhard Neck, Vincenzo Niola, Ka-Lok Ng, G. Enescu University, Iasi, Romania, June 13-15, 2012, WSEAS Press, ISBN: 978-1-61804-099-2
Book Chapters
Wang JD and Ka-Lok Ng* (2009). Scaling Behavior of Maximal Repeat Distributions in Genomic Sequences. A Randomize Test Follow Up Study, Ch.28, Discoveries and Breakthroughs in Cognitive Informatics and Natural Intelligence,.524-531, Yingxu Wang, Ed., IGI Global Book Series. Canada, ISBN: 1948-9722
Nilubon Kurubanjerdjit, Ka-Lok Ng* (2017). Bioinformatics analysis of microRNA and protein-protein interaction in host-pathogen interaction system, Computational methods with applications in bioinformatics analysis, Editors: Jeffrey J. P. Tsai, Ka-Lok Ng, World Scientific. ISBN: 978-981-3207-97-4